Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zanker, M.
Effects of prolonged fasting on glucose metabolism and hormone regulation in healthy, obese, and people with type 2 diabetes.
Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2020. pp. 34
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Sourij Harald
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- Abstract:
- In this study we investigated the effect of midterm-fasting (36h) compared to overnight fasting (12h) on plasma glucose levels and postprandial glucose disposal in healthy, obese, and people with type 2 diabetes. During a two-part prospective fasting intervention-study, all participants fasted for 12 hours for the first and 36 hours for the second visit. To evaluate the changes of glucose metabolism, glucoregulatory hormones and insulin response we performed an oral glucose tolerance test (OGTT) following 12 and 36 hours of fasting. In total we included 60 participants in this study (f, m, age: 23 to 74 years). From those 60 subjects 20 were healthy (11m, 9f, age: 32±10 years, BMI: 22.6±1.7 kg/m²), 20 obese (11m, 9f, age: 37±10 years, BMI: 34.6±4.8 kg/m²) and 20 were people with type 2 diabetes (15m, 5f, age: 60±23.9 years, BMI: 31.0±7.1 kg/m²). Following results were obtained after 12 and 36 hours of fasting: Fasting glucose- and insulin values were significantly reduced in all three study groups after 36 hours of fasting. Insulin sensitivity, determined by HOMA-IR and QUICKI, was remarkably increased following the prolonged fasting of 36 hours (HOMA-IR 12h vs. 36h: Healthy 0.86(0.75 – 1.41) vs. 0.43 (0.27 – 0.67), p=0.001; Obese 2.52 (1.72 – 4.27) vs. 1.37 (0.90 – 3.07), p=0.001; T2DM 4.26±2.06 vs. 3.17±2.17, p=0.012; QUICKI 12h vs. 36h: Healthy 0.39 (0.37 – 0.40) vs. 0.45 (0.41 – 0.49), p=0.000; Obese 0.33 (0.31 – 0.35) vs. 0.36 (0.32 – 0.39), p=0.021; T2DM 0.31 (.30 – 0.33) vs. 0.32 (0.31 – 0.37), p=0.001). Postprandial changes were only observed in healthy subjects as the plasma glucose levels 120 minutes post- OGTT and the glucose AUC notably increased after having fasted for 36 hours. (PG 120min 12h vs. 36h: 79.4±18.4 vs. 108.7±31.0 mg/dL, p=0.001; Glucose AUC 12h vs. 36h: 17070±3128 vs. 21627±4002 mg min/dL, p=0.000). In conclusion a one-time fasting period of 36 hours causes a significant postprandial glucose increase in healthy, a similar however non-significant effect in obese and no difference in type 2 diabetes.