Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Negrean, I.
Effect of thoracic diameter and food intake on FibroScan® results: Comparison of the S- and M-probes.
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 73
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Stadlbauer-Köllner Vanessa
- Altmetrics:
- Abstract:
- Background & Aims: Fibroscan® (Echosens, France) to assess liver stiffness (LS) non-invasively and painlessly is commonly used to determine the degree of fibrosis/cirrhosis. The manufacturer proposes to use the S-probe in patients with a thoracic circumference (TC) between 45 cm and 75 cm (TC<75 group) and the M-probe for patients above 75 cm (TC>75 group), always in fasting condition. We compared the influence of TC as well as the impact of a standardized liquid meal on the LS of the S- and M-probe in healthy volunteers. Methods: Healthy volunteers were assessed with the S- and the M-probe in fasted state and 30, 60 and 120 minutes after a standardized meal (200 ml Fresubin Energy Drink, Fresenius-Kabi, Germany). Liver stiffness and controlled attenuation parameter (CAP) were assessed. Results: 50 heathy volunteers (26 female, 24+/-3 years) 22 with a TC <75 and 28 with a TC >75 (range 58-99cm) were included. The TC<75 group was mainly female (n=19, p<0.001) with lower BMI (p<0.001). LS measurements were significantly higher in the TC>75 group. Comparison of the measurements obtained with the S-probe and the M-probe showed excellent agreement with minimal bias on various tests (Spearman correlation r=0.754, p<0.001, Bland-Altman bias 0.6 +/- 0.9 kPa, linear regression r2=0.557, p<0.001). After a standardized meal, no changes in LS were observed compared to baseline in any group. In volunteers with TC>75 CAP remained unchanged after the meal, but decreased slightly in the TC<75 group after 120min. Discussion: The S- and M-probe show good agreement in non-obese healthy adults both in adults below and above 75 cm TC and the intake of the standardized meal did not have a relevant influence on LS. In conclusion the probes may be used interchangeably in non-obese healthy adults.