Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lindorfer, T.
Does corneal collagen cross-linking promote the new appearance of iris freckles and iris nevi?
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 51
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Glatz Wilfried Maximilian
- Schwab Christoph
- Altmetrics:
- Abstract:
- Purpose: We aim to investigate, if corneal collagen cross-linking (CXL) is related to an increase in the number of iris freckles and nevi in treated eyes in comparison with untreated eyes. Patients and Methods: We conducted a prospective observational, cross-sectional, single-center study. Volunteers with history of unilateral CXL had bilateral iris images taken. We determined iris pigmented lesion counts for each iris quadrant by image inspection and compared the results of post-CXL eyes versus non-CXL eyes. In additional analyses, we examined the possible effects of post-CXL time difference and participant age. Results: Data of 20 participants were evaluated. No significant increase in iris pigmented lesion count was found between post-CXL eye to the non-CXL eye, except for the inferior nasal quadrant, though small in magnitude. No significant correlation between iris pigmented lesion count and CXL-to-examination time difference was detected. The number of iris pigmented lesions also did not significantly correlate with age. Conclusions: In our study population, we detect no clear indication of CXL leading to an increase in the number of iris freckles and nevi.