Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reitbauer, P.
The impact of hypoglycemia on platelet function and coagulation parameters in subjects with type 2 diabetes.
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 73
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Aberer Felix
- Sourij Harald
- Altmetrics:
- Abstract:
- Aims: Chronic hyperglycemia in type 2 diabetes mellitus (T2DM) causing cardiovascular disease has been an essential subject of research in diabetology in the last decades. Recent theories reveal that hypoglycemic events in diabetes is involved in the development and occurrence of cardiovascular disease. For instance, in the ACCORD study, an intensive glucose lowering therapy regimen in type 2 diabetes was associated with a higher risk of cardiovascular disease and mortality. In this thesis a review of existing literature regarding the influence of hypoglycemia on the cardiovascular metabolism and data of an experimental trial, DIAPLATE, will be presented. Methods: In the depicted study, 14 subjects with T2DM (10 men and 4 women, age 55 ± 7 years, HbA1c 51 ± 7 mmol/mol) without established cardiovascular comorbidity and treated with metformin monotherapy were included to a monocentric, open, single arm and mechanistic study. The acute and prolonged (up to one week) effects of a stepwise hyperinsulinemic-hypoglycemic clamp experiment (63 mg/dL and 45 mg/dL, for 30 minutes respectively) on markers of platelet aggregation, coagulation, endothelial function as well as inflammation were investigated. Results: A significant increase in PAC1posCD62Ppos, PAC1posCD63pos and PAC1posCD62PposCD63pos positive platelets, PAI-1, fibrinogen, factor VIII, von Willebrand factor and D-Dimer as well as in VCAM and ICAM was observed. These effects were observed during the experiment but especially one week after the investigation. Therefore, the DIAPLATE study supports and enhances existing literature, delivering evidence for the connection between hypoglycemic events and prothromboembolic and proinflammatory processes in T2DM.