Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Steinwender, M.
The influence of a multispecies probiotic on the health-related quality of life in patients undergoing long term proton pump inhibitor therapy.
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 85
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Horvath Angela
- Stadlbauer-Köllner Vanessa
- Altmetrics:
- Abstract:
- Background Proton pump inhibitors (PPIs) are frequently prescribed worldwide. Like any other drug, they come with side effects, one of them is alteration of the human gut microbiome. Changes in the microbiome have been associated with intra- and extra-intestinal diseases, severely influencing quality of life (QoL). This study aims to test if probiotics can positively influence the QoL in patients undergoing long term PPI therapy. Material and Methods In a single centre, open label, uncontrolled interventional pilot study between 2017 and 2018, 56 patients (under PPI therapy for at least 6 months) were enrolled at the Medical University of Graz to take probiotics for 3 months. QoL was assessed using SF36 and GIQLI questionnaire before intervention, after intervention and after 3 months of follow-up. Results 39 (20 male 19 female) patients were suitable for analysis. In GIQLI, probiotics led to better Symptoms scores (53.5; 48; 60.5 vs. 60; 52.5; 65.5, p=0.006), Emotions scores (14.5; 11.8; 17 vs. 16; 12.3; 19, p=0.018) and Overall scores (99; 88.3; 114.5 vs. 108; 100; 121, p=0.003) (Median; Q1; Q2, [points], before vs. after). During intervention no HRQoL concept decreased significantly. During follow-up period, decreases in QoL were observed in SF36: physical functioning (80; 50.3; 93.9 vs. 62.5; 47.5; 90; p=0.032; before intervention vs. follow-up), social role functioning (100; 75; 100 vs. 75; 53.1; 100, p=0.015; after intervention vs. follow-up); as well as in GIQLI: Social Items (13; 9.5; 16 vs. 11; 8; 14, p=0.012; after Intervention vs. follow-up) and Medical Treatment (4; 3; 4 vs. 3; 2; 4, p=0.009; after intervention vs. follow-up). Conclusion Probiotics might represent an appropriate supplement which is capable to increase the QoL in patients undergoing long term PPI therapy by decreasing bowel symptoms and improving emotional wellbeing. To get more conclusive information further investigation is needed.