Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Traub, J.
Microbiome and sarcopenia in patients with liver cirrhosis.
Doktoratstudium; [ Dissertation ] Universitaet Wien; 2020. pp.169.
- Autor*innen der Med Uni Graz:
- Traub Julia
- Betreuer*innen:
- Stadlbauer-Köllner Vanessa
- Altmetrics:
- Abstract:
- Malnutrition and sarcopenia are common but frequently overlooked complications in patients with liver cirrhosis. The assessment of sarcopenia and malnutrition in liver cirrhosis patients is challenging because of the influence of ascites, peripheral oedema and fluid retention. Hence, conventional screening tools may not be valid. To determine sarcopenia, different consensus definitions co-exists, whereas the EWGSOP (European Working Group on Sarcopenia in Older People) are the most frequently used definition criteria. Also, the gut-muscle-axis and changes in the diversity of the microbiome may play an important role in the development of sarcopenia. There is a link between alterations of the gut microbiome and chronic inflammation, anabolic resistance, reduced muscle size, impaired muscle function and adverse clinical outcome. Therefore, the aim of the present theses was to determine the incidence and severity of sarcopenia by using different consensus definitions and to compare different malnutrition screening tools, which are suitable to determine the risk of malnutrition in patients with liver cirrhosis. Additionally, we aimed to investigate the composition of the gut microbiome in liver cirrhosis patients with and without sarcopenia and controls and to prove the impact of oral nutrition supplements (ONS) on the gut microbiome. We showed that there is a high prevalence of pre-sarcopenia and sarcopenia (68%) in liver cirrhosis patients. We also found a significant difference in sarcopenia diagnosis using the EWGSOP 2010 and 2019 definition criteria as a result of the different starting points and cut-off values within the diagnostic process. These data suggest that further refinement of cut-off points and assessment tools is necessary to improve diagnostic accuracy. Using specific cut-off points for muscle mass and muscle strength for a particular patient population seems necessary to tailor the definition of sarcopenia to the disease population...