Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Boedendorfer, B.
Differences in the antibiotic film effect of cobalt-chromium-molybdenum implant surface coatings using Staphylococcus bacteria.
[ Diplomarbeit/Master Thesis (FH) ] FH Joanneum; 2020.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Lohberger Birgit
- Paulitsch-Fuchs Astrid Helga
- Altmetrics:
- Abstract:
- The medical field of implant research has been testing the use of body replacement materials for several decades. Their relevance has become more important since then and implants are in great demand due to increasing life expectancies. One major problem, however, that comes along with the introduction of an implant, is the possible accumulation/infection with bacteria and the development of a biofilm, which not only causes rejections of the implant, but in the worst case also leads to amputation of body parts. For this reason, attempts are being made to decrease the adhesion rates of bacteria by modifying alloy surfaces. In this project, conventional CoCrMo (cobalt-chromiummolybdenum) platelets were compared with five modified forms (TiN, highpolished, porous, cpTi, TCP). For the comparison the number of bacterial cells on the tested materials (flow cytometric life/death measurement) as well as protein and polysaccharide values (photometric measurements) were performed. These data give a broad overview of the bacterial adhesion and survival on a given surface. Flow cytometric data revealed a uniform development of bacterial numbers on the tested surfaces. Differences were found primarily in the evaluation of the results of the proteins and polysaccharides, which also confirms that modified alloy surfaces have an influence on the biofilm mechanism and could have an effect on the patient. Additionally, general biocompatibility within the patient and general mechanical characteristics of the materials have to be considered before implantation.