Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Habenicht, V.
Comparison of office heart rate and mean 24-hours ambulatory heart rate in chronic heart failure patients in relation to their ejection fraction.
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 68
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Verheyen Nicolas Dominik
- von Lewinski Dirk
- Altmetrics:
- Abstract:
- Background: Chronic heart failure poses a global disease with a prevalence of up to 2%. It comes with a high mortality rate, and is bound to a great financial burden, including extensive treatment costs. The pharmacological treatment of heart failure aims to improve the ejection fraction and lower the heart rate. The correlation between those two main targets is the main object of this work. Methods: Patients with chronic heart failure and a reduced ejection fraction of <50% were included in this ambulatory study. The central aim of this study was an evaluation of patient history, an assessment of systolic and diastolic dysfunction of the right and left ventricle, a 24-h ambulatory blood pressure and heart rate measurement and an office heart rate measurement. Blood samples were taken and laboratory parameters, such as NT-proBNP, were closely examined. Results: 99 patients, 20 female and 79 males, with a mean age of 64.8±9.6 years were included in the study. The mean left ventricular ejection fraction was 35.1±9% in the biplane and 34.1±9.3% in the 3D measurement. Median NT-proBNP was 1301.5 pg/mL (IQR: 346.51-2775.3pg/mL). The mean ambulatory heart rate measurements in the main study group were 68.3±10.9 bpm for the overall measurement, during the day 68.3±10.9 bpm and 63.9±10.7 bpm during the night. The mean office heart rate in sitting position was 68.5±13.3 bpm and 71.9±15.9 bpm in supine position (during 12-lead ECG measurement). Conclusion: The study has shown no significant correlations between different heart rate measurements and left ventricular ejection fraction. Mean ambulatory heart rate measurements strongly correlated with each other, as well as with the mean sitting office heart rate measurement. A single heart rate measurement during ECG did not correlate with the ambulatory heart rate measurements or the mean sitting office heart rate measurement. The significance of this finding remains unclear, and should be further investigated.