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Selected Publication:
Fitzek, K.
EVALUATION OF OXIDTIVE AND NITROSATIVE STRESS IN YOUNG FEMALES OF DIVERSE NUTRIONAL STATUS AND LIFESTYLE BEHAVIOR.
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2020. pp. 77
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- Authors Med Uni Graz:
- Advisor:
- Holasek Sandra Johanna
- Lackner Sonja
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- Abstract:
- Background and aim: Oxidative stress is determined by an imbalance of pro- and anti-oxidative mechanisms including inflammatory conditions and leads to destructive processes in the organism. It is one of the major risk factors for the development of non-communicable diseases. An excess of emerging reactive nitrogen species induces nitrosative stress. It has been shown previously that oxidative and nitrosative stress are associated with the BMI and the lifestyle of humans. The aim of this thesis was to retrospectively evaluate oxidative and nitrosative stress in young females of different nutritional status and put the results into a possible context of nutritional intake, activity level and depression status. Methods: Demographic, anthropometric and lifestyle associated data of a cohort of 107 young females of five different nutritional status (18 anorexia nervosa (AN) patients, 27 normal weight women, 22 overweight women, 20 adiposity subjects and 20 athletics) were collected. Total antioxidant capacity (TAC), total oxidant capacity (TOC), endogenous peroxidase activity (EPA), autoantibodies against oxidized low-density lipoprotein (oLAb) and malondialdehyde-modified low-density lipoprotein (MDA-LDL-IgM), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were measured in serum. Results: Significant higher serum TOC was found in obese compared to normal weight women (p = 0.001) and AN-patients (p < 0.001), additionally TOC was significant higher (p = 0.008) in athletes than in AN-patients. Athlete group showed significantly lower (p = 0.048) oLAb titres compared to overweight. AN-patients had significant lower ADMA levels than normal weight (p = 0.007), overweight (p = 0.033) and obese (p = 0.002). Furthermore a positive correlation between BMI and TOC, EPA and ADMA as well as a negative correlation between BMI and MDA-LDL IgM and SDMA were found. ADMA was also negative correlated with HAMD score. Conclusion: In the investigated collective, obese young women were more affected by oxidative stress than women of the same age who were not overweight. Young female athletes showed lower oLAb titres than obese women. AN-patients showed stronger signs of nitrosative stress than healthy young women. The available data complement the previous findings on the relationship between lifestyle and oxidative/nitrosative stress with special attention to nutritional status.