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Selected Publication:
Wundara,D.
Outcome of patients with ARDS (acute respiratory distress syndrome) and extracorporeal veno-venous membrane oxygenation - retrospective study
Humanmedizin; [Diplomarbeit] Medical University of Graz;2019. pp. 58
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- Authors Med Uni Graz:
- Advisor:
- Hackl Gerald
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- Abstract:
- Introduction: The acute respiratory distress syndrome (ARDS) is a serious, high-mortality disease. Since the 2009 influenza H1N1 epidemic in Australia and New Zealand the benefit of ECMO-therapy in patients with ARDS is discussed widely. At present, this therapy is only recommended as a rescue treatment for severe ARDS, as no significant survival benefit has been demonstrated over conventional therapy. The Sequential Organ Failure Assessment (SOFA) Score represents an already validated outcome predictor of various clinical conditions in intensive care units (ICU). In the present study, the 30-day mortality of ARDS patients treated with an ECMO procedure was evaluated by the SOFA-scores collected at the day of ECMO installation. Material and Methods: This retrospective data analysis included all ARDS patients treated with an ECMO procedure at the ICUof the Department of Internal Medicineof the Medical University of Graz. The SOFA-score was recorded at the day of ECMO installation. Statistical methods were used to investigate whether the 30-day mortality differs depending on the SOFA-score. Results: 34 patients were included in the study (59% male, mean age 55±13 years). Of these, a total of 21 patients (62%) died due to their ARDS. The 30-day mortality was 59% (n=20). The mean SOFA-score was 13±3 points. Although the SOFA-score differed significantly between the group of survivors and the deceased (p=0.04), there were no relevant differences in the 30-day mortality between survivors and non survivors (p=0.37). Conclusion: The mortality in this study is slightly above the mortality rates described in the literature. The SOFA-score is not a relevant 30-day mortality predictor for ARDS patients in the present study.