Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Asamer, E.
Elevated amylase in plasma represents an adverse prognostic marker in patients with metastatic pancreatic cancer
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2019. pp. [OPEN ACCESS]
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Autor*innen der Med Uni Graz:
Betreuer*innen:: Pichler Martin; Stotz Michael
Altmetrics:
Abstract:: Background and aim: Clinical outcome of metastatic pancreatic cancer (PC) patients is dismal and novel prognostic factors might help to stratify patients into different risk groups in clinical trials and clinical decision-making. Lipase and Amylase are recommended markers for diagnosis of acute pancreatitis, but their significance with regard to prognostic relevance in metastatic PC is uncertain. The aim of this study was to investigate the prognostic relevance of these two parameters concerning survival of patients suffering from metastatic PC. Method: This large retrospective study includes 351 patients with metastatic PC, who were treated between the years 2004 and 2015 in a single academic institution. Cancer-specific survival (CSS) was analysed using the Kaplan-Meier method. To further evaluate the prognostic significance of lipase and amylase, univariate and multivariate values were calculated using Cox proportional models. Results: In our study cohort, amylase and lipase values were highly correlated (R=0.821, p<0.001). In univariate analysis, an increased amylase level was associated with shorter CSS in PC patients (HR=1,258; 95%CI=1,011-1,566; p=0,039). In multivariate analysis, including gender, age, CA19-9 and administration of chemotherapy, increased amylase levels prevailed as an independent prognostic factor for CSS (HR=1,373; 95%CI=1,004 – 1,878; p=0.047). Discussion: Plasma amylase was identified as an independent prognostic factor in metastatic PC patients. Our results indicate that amylase might represent a novel and useful marker for better patient stratification in PC management.