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Kohlhauser, M.
MRT-basierte Bestimmung des Subkutan- und Vizeralfettvolumens: Einfluss des Schichtabstands und Vergleich mit dem Lipometer
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2019. pp. 71 [OPEN ACCESS]
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Authors Med Uni Graz:
Advisor:: Horejsi Renate; Möller Reinhard; Reiter Ursula
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Abstract:: Background and Purpose: Whereas the Lipometer allows for the fast estimation of subcutaneous (SAT) and visceral (VAT) fat volume from standardized meas-urement points, volumetric evaluation of SAT and VAT from magnetic resonance tomography (MRT) image stacks covering the torso with gapless slices is time consuming. The aim of this diploma thesis was on the one hand to evaluate, if SAT and VAT can be accurately derived from volumetric evaluation of reduced MRT image stacks with gaps between the slices, on the other hand to analyze the correlation of reduced MRT data sets with SAT and VAT measured by the Lipome-ter. Methods: 25 healthy subjects were included in the prospective study. SAT and VAT volumes were measured with the Lipometer and 3T MRT using a 3D VIBE DIXON sequence. A stepwise reduction of gapless MRT image stacks to every 2nd, every 4th, …, every 64th slice was performed in a subpopulation of 14 subjects. For the comparison of Lipometer- and MRT (stacks reduced to every 16th slice)-derived SAT and VAT volumes all subjects were included in the evaluation. SAT and VAT volumes were compared by paired t-test, correlation and regression analysis. Results: SAT and VAT volumes assessed from reduced MRT image stacks re-vealed very strong correlations to SAT and VAT derived from evaluation of the entire image stack: Stepwise reduction of the stack from including every 2nd to every 64th slice resulted in linear correlation coefficients of r = 1.0000 – 0,9616 for SAT and r = 0,9991 – 0,9864 for VAT. Comparing the Lipometer- and MRT-based volumetric evaluation of every 16th slice resulted in correlations of r = 0,9021 for SAT und r = 0,8534 for VAT. Conclusions: The present study showed that SAT and VAT can be evaluated from MRT slices with gaps without significant losses in information, resulting in an essential reduction of MRT evaluation time of SAT and VAT. The strong correlations between results of the two methods allow for conversion of Lipometer- and MRT-based SAT and VAT volumes into one another.