Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Prettenhofer, A.
Evaluation of Psychosomatic Parameters during the Intake of Probiotic Supplements in Bipolar Affective Disorder
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2019. pp. 54
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Birner Armin
- Reininghaus Eva
- Altmetrics:
- Abstract:
- The microbiome can influence mood and interferes with the course of certain illnesses. Various studies have shown that the microbiome relates to psychiatric diseases, like Morbus Alzheimer and depression, but only a few, to the date, have investigated its relation to bipolar disorder. To further elucidate the topic of microbiome and psychiatric diseases, the pilot study „Wirkung von Probiotika auf kognitive Funktionen bei Menschen mit bipolarer Störung in euthymer Stimmungslage“ was started at the Medical University of Graz under the supervision of Assoz. Prof.in Dr. Eva Reininghaus. This study seeks to explore the influence of probiotic supplements on mood, digestion and sleep. Based on this study, many examinations– including this thesis– were initiated in order to gain deeper knowledge about the relation between bipolar disorder and the microbiome. As a result, this thesis shows that probiotic supplement treatments result in there are both subjective and quantitative, alterations in the quality of life of an individual diagnosed with bipolar disorder. RM-ANOVAS and IBM SPSS 22 were used to analyze the applied questionnaires. Improvements of mood, digestion and sleep could be shown, including a significant reduction of manic and depressive symptoms. In detail, 56% (= 15 patients) noted an improvement in the digestion and 30% (= 8 patients) did experience an enhancement in their mood. A significant decrease of manic symptoms has been noted in the Mania Symptom Scale-questionnaire (p=0.048, F(2,18)=3.621), which was filled out by the probands as well as in the Young Mania Rating Scale-questionnaire (p=0.023, F(2,17)=4.751). Concerning the depressive symptoms, a significant decline was determined in the rumination subscale (p=0.037, F(1,20)=3.988) of the Leiden Index of Depression Sensitivity-Revised score between visit two and three. The results of this pilot study suggest diverse effects of probiotic supplements on somatic and psychiatric symptoms in euthymic individuals with bipolar disorder and serves as an impetus for further research on this topic.