Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Breiteneder, M.
Retrospective evaluation of the potential prognostic value of the preoperatively assessed eosinophil granulocyte counts regarding clinical outcomes in non-metastatic clear cell renal cell carcinoma patients
Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2019. pp. 38
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Hutterer Georg
- Pichler Martin
- Altmetrics:
- Abstract:
- Objective: Renal cell carcinoma (RCC) represents the most common malignant tumour of the adult kidney. Distinguishable inflammatory parameters like the haemoglobin concentration, platelet counts and absolute leukocyte counts have been demonstrated to influence tumour activity and thus might play an important role as prognosticators of survival in various types of cancer. We investigated the potential prognostic significance of the pretreatment eosinophil granulocytes count in a large European cohort of patients with non-metastatic clear cell RCC. Material and Methods: Clinico- pathological data from 677 consecutive, non-metastatic clear cell RCC patients, operated between 2000 and 2010 at a single tertiary academic center, were evaluated retrospectively. Pretreatment laboratory parameters were assessed within one week before surgery. Patients were categorized using a eosinophil granulucytes-cutoff value of 200/µl according to a calculation by receiver-operating curve (ROC) analysis. Overall survival (OS) was assessed using the Kaplan-Meier method. To evaluate the potential prognostic significance of the pretreatment eosinophil granulocytes count, a multivariate Cox regression model was performed. Results: In multivariate analysis, age at operation (<65 vs. 65yrs., HR=1.037 [95% CI=1.023-1.052], p<0.001), tumour grade (G1+G2 vs. G3+G4, HR=1.329 [95%CI=1.036-1.704],p=0.025), pathologic T-stage (T1 vs. T3+T4, HR=1.387 [95%CI=1.017-1.891], p=0.039), as well as an elevated pretreatment eosinophil granulocytes count (<200/l vs. >200/l,HR=1.472 [95%CI=1.103-1.964], p=0.009) achieved independent predictor status regarding OS, respectively. Conclusion: In the cohort studied, an elevated pretreatment eosinophil granulocytes count was confirmed as an independent predictor of OS in the non-metastatic clear cell RCC setting.