Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pollak, C.
Type-II Diabetes in the course of Bipolar Disorder
Correlation between Type-II Diabetes and clinical parameters within Bipolar Disorder
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2018. pp. 64
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Fellendorf Frederike
- Reininghaus Eva
- Altmetrics:
- Abstract:
- Introduction: People with bipolar disorder suffer from comorbid somatic disorders with disproportional frequency. Metabolic disorders such as overweight and diabetes mellitus in particular, associated with systemic inflammation and cognitive deficits have an especially high prevalence and their occurrence increases during the course of the illness. Objective: This study analysed the prevalence of diabetes mellitus, fasting glucose and hba1c levels of individuals with bipolar disorder in comparison to mentally healthy controls. Moreover, we aimed to identify parameters which indicate a causal link for diabetes mellitus in the course of a bipolar disorder on the basis of an own defined diabetes mellitus “risk score”. Methods: Within the scope of the BIPFAT study carried out at the University Hospital of Psychiatry and Psychotherapeutic Medicine of the Medical University of Graz data on medication, disease specific parameters, laboratory test values, body-mass index as also smoking and exercise habits were surveyed in 245 euthymic patients with bipolar disorder and 142 mentally healthy control persons. Furthermore, differences between patients and healthy controls were analysed and correlations between the risk score and several clinical parameters established. Results: The occurrence of diabetes mellitus was higher in individuals with bipolar disorder compared to the control group. Furthermore, calculations showed that male patients had a significantly higher diabetes mellitus risk score compared to female patients. We found relationship between higher inflammation parameters (CRP, IL-6) and an increased diabetes mellitus risk score in individuals with bipolar disorder. No correlates could be established in the other additional calculated factors such as glucose metabolism, life-style habits (smoking, exercise), medication and clinical classification (bipolar I versus II). Discussion: In summary, it can be proposed that patients with bipolar disorder have an increased risk of developing diabetes mellitus. Chronic low-grade inflammation as well as gender seems might be associated factors. Since diabetes mellitus is associated with high mortality rates, a screening should take place at an early stage of bipolar disease in order to prevent the outbreak of a manifest diabetes mellitus.