Medizinische Universität Graz - Research portal
Selected Publication:
Silber, I.
Metabolic programming by maternal obesity
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2018. pp. 90
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- Authors Med Uni Graz:
- Advisor:
- Hiden Ursula
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- Abstract:
- Background: Obesity is a worldwide problem and its prevalence is increasing rapidly. Maternal obesity is considered to be one of the influencing factors by affecting the offspring during pregnancy. The exact pathophysiology of how maternal obesity influences the offspring in utero and thus, long-term, is still unclear, but metabolic imprinting has been suggested to play an important role. Maternal obesity is associated with different adverse consequences for the offspring, for instance, increased risk at adiposity, adverse cardiovascular outcomes and insulin resistance. The aim of this review was to give a comprehensive overview of the association between maternal obesity and long-term adverse outcomes in the offspring. Methods: This review was conducted by researching the online data base PubMed for human-orientated publications. All in all, 73 publications, published between 2005 and 2017, were used. Basic information was found in books, the WHO website and PubMed. Results: Maternal obesity is associated with a lot of adverse outcomes in the offspring. The results were grouped according to the affected organ systems or phenotype. The most impressive result was the impact of maternal obesity on the offspring’s risk at obesity in later life. Conclusion: Obesity does not only influence the expecting mother, but also affects the offspring tremendously. Thus, a healthy lifestyle, especially during the periconceptional period, is important to ensure a healthy pregnancy and reduce the offspring’s risk at later life disease.