Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kollmann, M.
Androgen metabolism and reproductive outcome
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2018. pp. 98
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- Autor*innen der Med Uni Graz:
- Kollmann Martina
- Betreuer*innen:
- Klaritsch Philipp
- Lerchbaum Elisabeth
- Obermayer-Pietsch Barbara
- Altmetrics:
- Abstract:
- Introduction: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder which occurs in about 10% of women in reproductive age, affects several body systems and leads to reproductive and metabolic complications. Women with PCOS suffer from impaired fertility and higher complication rates during infertility treatment, pregnancy and the perinatal period. The superordinate aim of the project was the investigation of the perinatal period of women with PCOS. Material and Methods: Three studies were designed and performed at the Medical University of Graz. The first study (1) was a retrospective matched cohort study designed to compare the prevalence of adverse maternal and neonatal outcomes in pregnant women classified with PCOS according to different definitions. The second study (2) was a prospective cohort study investigating serum levels of androgens and anti-Müllerian hormone (AMH) before, during and after pregnancy, and the perinatal outcome of pregnant women with PCOS. The third study (3) was a prospective cohort study evaluating whether androgen and AMH levels in the offspring of women with PCOS are different from those of women without PCOS and whether the perinatal outcome of PCOS and non-PCOS women is different. Results and Conclusion: (1) Regardless of the PCOS definition, about 60% of women with PCOS and about 30% of their infants were subject to perinatal and neonatal complications. In comparison to healthy controls, the risk for maternal complications was significantly increased in PCOS women, while there was no difference in neonatal complications. (2) Androgen (testosterone, free testosterone, and androstenedione) and sexual hormone binding globulin (SHBG) levels increased throughout pregnancy, while those of dehydroepiandrosterone sulphate (DHEAS) and AMH decreased. (3) Androgen levels in female offspring of PCOS and non-PCOS women did not differ, although maternal hormone levels differed significantly. Postnatal hormone levels were not different in girls and boys of women with PCOS as compared to those without PCOS women; only androstenedione levels were higher in boys of PCOS women.