Medizinische Universität Graz - Research portal
Selected Publication:
Ehsas, H.
Can Volume wave velocity replace Pulse wave velocity?
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2018. pp.78
[OPEN ACCESS]
FullText
- Authors Med Uni Graz:
- Advisor:
- Zweiker Robert
- Altmetrics:
- Abstract:
- Abstract Aims The aim of this diploma thesis is to prove whether the Pulse wave velocity (PWV) can be replaced by the Volume wave velocity (VWV). Furthermore, we want to demonstrate that the parameters which have been shown in the past to correlate with PWV also correlate with the newly defined term “VWV”. Background Pulse wave velocity is the gold standard for the assessment of aortic stiffness. The execution of the measurement is very time-consuming. Therefore, it is hardly ever measured in clinical routine. However, since aortic stiffness has an immense impact on the outcome of patients with cardiovascular diseases we aimed to introduce a completely new methodology for the assessment of aortic stiffness. Materials and Methods 1317 measurements of the VWV were performed by the CombynTM-ECG, developed by Professor Falko Skrabal. Furthermore, blood samples were taken from the patients during the routine examination. We included cholesterol levels (LDL and HDL), lipoprotein a, triglycerides, inflammatory markers (CRP and ESR), renal parameters (creatinine and uric acid), HbA1c and BNP in our statistical analysis. All the data were exported to Excel. The statistical analysis was performed with IBM SPSS Statistics 23 ©. For the recording of the volume wave velocity the acceleration of blood was measured at 40 kHz at the onset of arms and legs. The individual lengths of the trunks were measured and from the time delay of the leg and arm signal volume wave was calculated. Results Based on the collected data, in multiple regression analysis we were able to show highly significant correlations between the volume wave velocity and the following parameters: age (R=0.703; p<0.001), body height (R=0.680; p<0.001), HDL (R=0.404; p<0.001), LDL (R=0.786; p=0.004), Triglycerides (R=0.404; p=0.001), CRP (R=0.404; p<0.001), HbA1c (R=0.624; p<0.001), ESR (R=0.303; p=0.018), uric acid (R=0.303; p=0.01), systolic blood pressure (R=0.774; p<0.001) and diastolic blood pressure (R=0.624; p=0.001). Conclusion Since we show significant correlations of VWV for all the parameters for which correlations with PWV had been demonstrated in the past we conclude that VWV can probably replace the tedious measurement of PWV. The prevention of progression of aortic stiffness will probably play an important role in the future. Therefore, the routine assessment of aortic stiffness should be included in the routine cardiovascular screening. Our aim is to introduce the measurement of volume wave velocity in the daily clinical routine. Since it`s measurement can be performed without time delay during a ECG-recording, this could be important step into that direction. Key words Volume wave velocity, aortic stiffness, CombynTM-ECG, impedance measurement