Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rogatsch, M.
Epidemiological and clinical characteristics of patients with multiple primary melanomas. A retrospective data analysis and review of the literature.
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2018. pp. 61
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Hofmann-Wellenhof Rainer
- Zalaudek Iris
- Altmetrics:
- Abstract:
- Background. With a rising incidence of malignant melanoma (MM), the rate of patients developing more than one melanoma during their life course is increasing. Over the past years, new insight on the risk factors and the development of multiple primary melanomas (MPM) was gained. This study addresses the issue of sex-specific differences in the clinical presentation of MPM. Methods. Data of patients presenting with subsequent primary melanomas between the years 2010 – 2016 at the Dermatology department of the Medical University of Graz were obtained. Following an initial evaluation, a retrospective analysis of the clinical data with a focus on sex-specific differences was conducted. Results. In our study collective of 87 patients, a total of 263 melanomas were diagnosed between the years 1973 and 2016. The mean age was 68 years (range: 34 to 92 years). Forty-six percent of the patients were women. The most common anatomic location in both sexes was the trunk (47.2%) followed by the upper extremity (21.2%). Women were younger at the time of the first diagnosed MM with a mean age of 54 years compared to 61 years in men. The difference between the medians was 12.5 years (p = .031). Furthermore, in women the presence of dysplastic nevi was associated with younger age (p < .001). In men, a higher rate of consecutive MM was reported after the fifth year of the previous diagnose (28.9% vs. 16.3% in women). Breslow thickness was lower in the subsequent melanomas of male patients compared to the first diagnosed melanoma (p < .05). Conclusion. Our study suggests some novel gender-related differences in patients affected by multiple primary MMs.