Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rief, P.
Bleeding complications in outpatients treated with anticoagulation for venous thromboembolism: clinical relevance of the HAS-BLED bleeding score
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] 5; 2017. pp.
[OPEN ACCESS]
FullText
- Autor*innen der Med Uni Graz:
- Rief Peter
- Betreuer*innen:
- Brodmann Marianne
- Cvirn Gerhard
- Gary Thomas
- Altmetrics:
- Abstract:
- Objectives: The aim of this study was the prospective evaluation of the performance of the HAS-BLED score in predicting major bleeding complications in a real-world outpatient cohort, during long term anticoagulation for venous thromboembolism (VTE), treated with a broad spectrum of anticoagulants. Methods: We analyzed 111 outpatients objectively diagnosed with VTE and treated long term with various anticoagulants. Patients were grouped in three cohorts based on anticoagulant regimen. Calculation of the HAS-BLED score and documentation of bleeding events was performed every six months for one year. Results: Patients with a HAS-BLED score =3 had an increased risk for major bleeding events (odds ratio (OR) 13.05, 95% confidence interval (CI): 0.96 - 692.58, p = 0.028) and a trend to higher risk for minor bleeding events as well (OR 2.25, 95%CI: 0.87 - 5.85, p = 0.091) when compared to patients with a HAS-BLED score <3. Conclusion: This indicates that a HAS-BLED Score =3 allows for identification of VTE-patients on long-term anticoagulation at increased risk for major bleeding events, irrespective of the anticoagulant agent used.