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Selected Publication:
Schönbacher, L.
Correlations of prenatal Human Milk Oligosaccharides with maternal lipid profiles
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2017. pp. 63
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- Authors Med Uni Graz:
- Advisor:
- Jantscher-Krenn Evelyn
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- Abstract:
- Introduction: Human milk oligosaccharides (HMOs) are complex, unconjugated glycans highly abundant in human milk and serve as prebiotics, antiadhesive antimicrobials and cell modulators. As “prenatal HMOs” they emerge in the mother’s blood already during pregnancy from the early second trimester on, suggesting systemic functions. Potential environmental factors that influence the highly individual HMO composition have not been investigated so far. For this thesis, correlations between prenatal HMOs and blood lipids (mirroring one aspect of the mothers’ “metabolic situation”) have been analyzed. Materials and Methods: Blood lipids (triglycerides, total cholesterol, LDL, HDL) and 17 prenatal HMOs (24th week of gestation, measured by NP-HPLC) were analyzed in serum samples taken from 94 Dutch women, followed by a calculation of Spearman rank correlations. Results: Within the subgroup of secretor-positive women relative concentrations of 3’SLN positively correlated with LDL (r=0.42, p<0.001) and total cholesterol (r=0.39, p<0.001). 2’FL on the contrary correlated significantly negative with LDL and total cholesterol. Within secretor-negative women other correlations were found. Discussion: We here provide first evidence that elevated blood lipids are associated with specific configurations of prenatal HMOs. Detailed mechanisms of potential interactions remain to be investigated.