Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rauter, D.
Advantage of taking tissue samples for the histological examination during Dacryocystorhinostomy
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2017. pp.
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Tomazic Peter Valentin
- Walch Christian
- Altmetrics:
- Abstract:
- Background: Benign or malignant proliferative lesions of the lacrimal duct system are rarely seen in clinical practice, but still some patients are affected. During an endoscopic transnasal dacryocystorhinostomy, tissue sampling for histological examination is not routinely performed, although without a histological examination a malignant proliferative disease, such as a lymphoma or a malignant melanoma, cannot be detected. In this study, we tried to determine whether tissue collection during DCR allows incidental histological findings of benign or malignant proliferative diseases. Furthermore, we wanted to show that taking tissue samples during the procedure can improve the outcome with a decreased recurrence rate due to early diagnosed and early treated benign or malignant neoplasms. Methods: In this study we retrospectively analysed data of patients suffering from different diseases of the lacrimal duct system that were treated by endoscopic transnasal dacryocystorhinostomy at the Department of Otorhinolaryngology at the Medical University of Graz between June 2001 and April 2015. 364 patients fulfilled the inclusion criteria. Results: In the histological examination of 213 taken tissue samples, five incidental histological findings of a benign or malignant proliferative disease were detected. This equals a rate of incidental histological findings of 2.3 %. Furthermore, the recurrence rate of patients where tissue samples were taken (9.4 %) was significantly lower than in patients without biopsy (18.5 %) (p = 0,011). The recurrence rate in 336 patients with implanted stents (13.7 %) was higher than in the 28 patients without stents (7.1 %). Conclusion: Summing up the results of the statistical analysis, we can conclude that taking tissue samples for histological examination during DCR has advantages for the patients. One advantage is that through histological examination of the tissue, incidental findings of benign or malignant proliferative diseases can be detected. The other advantage is the decrease in recurrence rate of nasolacrimal duct stenosis. This decrease may be the result of an improved individually tailored postoperative drug therapy due to the results of the histological examination.