Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Haas, A.
Effect of intravitreal C3F8 gas in patients with vitreomacular traction – a retrospective case series
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2017. pp.
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Mayer-Xanthaki Christoph Fidel
- Wackernagel Werner
- Altmetrics:
- Abstract:
- Purpose: This case series tried to assess the efficacy of a single intravitreal perfluoropropane gas injection for the treatment of vitreomacular traction with or without a macular hole. Method: In this retrospective case series, 7 eyes of 6 patients with symptomatic vitreomacular traction documented on optical coherence tomography received a single intravitreal C3F8 gas injection of up to 0.3mL. The primary end point was vitreomacular traction release at one month after injection. Secondary end points included resolution of vitreomacular adhesion within six months, nonsurgical closure of macular holes and change in central foveal thickness and best-corrected visual acuity. Results: Overall, three of seven eyes (42.86%) had release of vitreomacular traction at 1 month after injection, with three further eyes (85.71%) releasing within six months documented on optical coherence tomography. Out of the latter two of the three eyes showed a concurrent epiretinal membrane and one a concurrent diabetic retino- and maculopathy. The patient with a macular hole had resolution of vitreomacular traction within one month but had to undergo vitrectomy because of nonclosure of the macular hole. Associated adverse events were a macular edema with a consequent lamellar hole after injection in one patient and another patient developed a retinal detachment. Conclusion: Intravitreal perfluoropropane gas injection is an inexpensive and promising minimally invasive option for the treatment of symptomatic and persistent vitreomacular traction with or without showing a macular hole. Further larger studies, especially contrasting C3F8 gas injection with other treatment options, are needed.