Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Forster, K.
Does intraluminal applied taurolidine confer an antimicrobial effect on the extraluminal central venous catheter surface?
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2016. pp. 72
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Krause Robert
- Altmetrics:
- Abstract:
- Catheter related bloodstream infections may originate from extra- or endoluminal catheter colonization with spread of microorganisms into the bloodstream. Catheter lock solutions are routinely instilled into catheters to prevent thrombosis and, if the solutions exert antimicrobial properties, to prevent catheter related infections from the endoluminal surface. We performed an in vitro time kill study to investigate whether antimicrobial lock solutions possess also an extraluminal antimicrobial effect by diffusion from the endo- to the extraluminal compartment. Two central venous catheters (silicone or polyurethane) either filled with taurolidine 1% or with saline were incubated within a broth containing either S. aureus or E. coli 10^8 and incubated for 48 hours. After incubation the extraluminal catheter surface was investigated by the semiquantitative roll-plate method to determine catheter colonization compared to controls (catheters filled with NaCl). Compared to controls endoluminal taurolidine showed no effect on catheter colonization on extraluminal catheter surfaces. We therefore conclude that taurolidine cannot diffuse through the catheter wall and has therefore no extraluminal antimicrobial activity.