Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Erath, M.
Evaluation of vitamin D and bone markers in patients with hepatitis B infection with and without tenofovir treatment
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2016. pp. 137
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Kessler Harald
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- Abstract:
- Background: Increased bone turnover rates as well as vitamin D deficiency and insufficiency have been observed in HIV-infected individuals receiving tenofovir disoproxil fumarate (TDF). There is a lack of data regarding the effects of TDF use on bone markers and vitamin D in HBV-infected individuals. Objectives: The aim of the present pilot study was to evaluate bone markers and vitamin D levels in HBV-infected patients with and without TDF therapy. Material and methods: A total of 41 HBV-infected patients attending the Division of Gastroenterology and Hepatology at the Medical University of Graz were enrolled including 23/41 patients with a serum HBV DNA level of =2000 IU/ml eligible for antiviral treatment (TDF Group) and 18/41 patients with a serum HBV DNA level of <2000 IU/ml (Non-TDF Group). TDF Group members received a daily dose of 300mg TDF. In this pilot study, the levels of 25-hydroxyvitamin D [25(OH)D], C-terminal cross-linked telopeptide of type I collagen (CTX), osteocalcin (OC), procollagen type I N-terminal propeptide (P1NP), and osteoprotegerin (OPG) were determined at baseline (BL) and followed-up three months thereafter (FU). Results: In TDF Group members, significant increases in serum levels of CTX (+46%) and OC (+24%) were observed three months after TDF initiation. High rates of vitamin D deficiency and insufficiency were found in both study groups at BL (TDF 87%, Non-TDF 61%) and at FU (TDF 87%, Non-TDF 67%), especially when blood was drawn in the winter season. There were no significant changes in both study groups regarding the serum levels of P1NP and OPG. Conclusion: Given the high rates of vitamin D deficiency and insufficiency found in both study groups it might be reasonable to screen HBV-infected individuals for hypovitaminosis D and to consider vitamin D and calcium supplementation. Prospective studies are required to evaluate whether the early increase of bone turnover observed in the present study is a short-term effect or a predictor of future bone loss.