Medizinische Universität Graz - Research portal
Selected Publication:
Wernigg, G.
The role of irreversible electroporation (IRE) as an ablation technique in interventional radiology
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2016. pp. 89
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- Authors Med Uni Graz:
- Advisor:
- Fuchsjäger Michael
- Wimmer Thomas
- Altmetrics:
- Abstract:
- The purpose of this thesis is to give a comprehensive overview of the current status of irreversible electroporation (IRE) in research and clinical practice as an ablation technique in interventional radiology. Imageguided percutaneous treatment techniques are gaining importance in interventional oncology as minimally invasive therapeutic option for patients not eligible for surgical tumor resection, as salvage therapy and even as primary therapy for small tumors. Irreversible electroporation, a relatively novel technique (introduced to clinical medicine in 2007), has certain benefits compared to well established thermal ablation techniques, but also possible drawbacks. The aim of this work is to give an overview ranging from the basic physical principles to state-of-the-art implementation of irreversible electroporation in Interventional Radiology. We furthermore want to deliver a thorough review of this technique based on current literature, including basic, translational science as well as clinical studies. In brief, we will also compare the outcomes of IRE to other ablation techniques and determine the fields in which it may be a superior choice of treatment. We will also try to give a fu-ture outlook on this fascinating matter. Comparative and systematic literature review will constitute the base of this work.