Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Woltsche, N.
Recurrent Nevus vs. Recurrent Melanoma
Differences in Epidemiology, BRAF-Mutation Status and Review of the Literature
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2015. pp.
[OPEN ACCESS]
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Massone Cesare
- Zalaudek Iris
- Altmetrics:
- Abstract:
- Introduction: Recurrent nevi are much more common than recurrent melanomas, differentiation often remains challenging. The aim of this study is to evaluate differences between recurrent nevi and recurrent melanoma regarding epidemiologic parameters and BRAF V600E mutation status. Material & Methods: The data of patients with recurrent nevi and recurrent melanoma treated at the Department of Dermatology & Venereology, Medical University of Graz during 2010 – 2015 was collected and evaluated regarding epidemiologic parameters. BRAF V600E mutation analysis was performed for the primary and the recurrent lesion in 50 patients with recurrent nevi, and for the primary and the recurrent lesion in 13 patients with recurrent melanoma. Results: A total of 177 patients with recurrent nevi and 28 patients with recurrent melanoma met the inclusion criteria for epidemiologic evaluation. Mean age of the patients with recurrent nevi was 31 years, whereas it was 65 years in patients with recurrent melanoma. The majority of recurrent nevi was located on the upper back and the extremities. Instead, recurrent melanoma was most commonly located on head/neck. The majority of nevi recurred in the first 12 months after initial diagnosis. The peak for recurrence in melanoma was 13-36 months. BRAF V600E mutation status in the primary and the recurrent lesion could be analyzed for 36 nevi patients and 12 melanoma patients. 11/36 nevi patients showed mutation in both, primary and recurrent lesion, 12/36 nevi patients showed mutation only in the primary lesion and 5/36 nevi patients showed mutation only in the recurrent lesion. 2/12 melanoma patients showed mutation in the primary lesion, while 3/12 melanoma patients showed mutation in the recurrent lesion. Conclusion: In summary, recurrent nevi were associated with age younger than 30 years, location on back and extremities and shorter time to recurrence, whereas recurrent melanomas were associated with age older than 65 years, location head/neck and longer time to recurrence. BRAF V600E mutation was more commonly detected in recurrent nevi than in recurrent melanoma.