Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Litscher, D.
Prevention and early intervention of lifestyle-related diseases by special evidence-based complementary medicine methods
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2015. pp.
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Holasek Sandra Johanna
- Petek Erwin
- Wang Lu
- Altmetrics:
- Abstract:
- Lifestyle-related diseases are a big problem all over the world. For example stroke is one of the leading causes of death worldwide. This thesis is about basic research concerning prevention and early intervention of lifestyle-related diseases by special evidence-based complementary medicine methods. The first chapter deals with yellow laser stimulation and the influence on high blood pressure. Among other parameters blood pressure (BP), heart rate (HR), heart rate variability (HRV), and temperature effects before, during, and after stimulation of different acupoints (Baihui, Neiguan, Taichong, placebo point) with yellow laser were investigated in 26 healthy volunteers at the Medical University of Graz. There were significant decreases after yellow laser acupuncture in the systolic BP, whereas HRV increased. The temperature during the yellow laser stimulation decreased significantly at all measured points. After the stimulation it increased again significantly. Also laser therapy in stroke is a very important topic. No one currently knows in detail the laser parameters that have to be chosen on the intact skull, so that the laser light can develop its possible efficacy inside the human skull. The present study in chapter 2 demonstrates that the values for the wavelengths 810 nm and 658 nm correlate well with previous experimental findings however the information on the yellow laser was estimated incorrectly by a factor of ten by other authors. A database analysis (PubMed, Cochrane Library) to examine the profile of publication activity related to dementia is included in chapter 3 in this thesis. About 600 papers related to the research area “dementia and laser” were found. First results concerning the measurement of the transmission factor through the human skull of a new LED- (light emitting diode-) based system are presented. The measurements show that this LED system (using the QIT (quantum optical induced transparency) effect) might be used in patients with dementia. The following chapter 4 is about an animal experimental trial in rats. The goal of this study was to investigate how red laser stimulation influences the temperature of 12 anesthetized rats (6 with deactivated laser) at different acupuncture points and non acupoints (Baihui, Zusanli, control point). Significant decreases in temperature were found at the acupoints Baihui, Zusanli left, and Zusanli right. In addition there was no significant temperature effect at a control point. Chapter 5 of this doctoral thesis is about new colored light stimulation. The aim of this pilot study was to investigate acute temperature, HR, HRV, and state of mind reactivities after illumination with red and blue light in seven healthy volunteers. Significant decreases were found only after 10 min blue light stimulation in nose temperature, HR, and total HRV, in association with a significant alteration of the emotional state. However, red light stimulation of the same persons did not induce the same effects in these parameters. In the publication of chapter 6, acute effects of a special kind of manual therapy (RegentK®) on regional oxygen saturation (rSO2) of knee tissues in patients with completely ruptured anterior cruciate ligament (ACL) were compared to standard physiotherapy. Twenty patients were enrolled in this study and randomly assigned to receive either RegentK® or physiotherapy. RSO2 increased significantly after RegentK® on both registration sites of the injured knee (anterolaterally, anteromedially), whereas after physiotherapy only the anterolateral side showed significant increases. The six chapters of the thesis clearly show the manifold possibilities of complementary and integrative medicine methods. In detail important basic research was performed in areas of laser acupuncture, laser and light therapy and manual and physiotherapy.