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Selected Publication:
Fischerauer, S.
Preclinical characterization of bioresorbable magnesium implants for osteosynthesis
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2015. pp.
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- Authors Med Uni Graz:
- Fischerauer Stefan Franz
- Advisor:
- Kraus Tanja
- Kühn Klaus-Dieter
- Weinberg Annelie-Martina
- Altmetrics:
- Abstract:
- Nowadays the requirements for biomaterials in osteosynthetic application are very high: New biomaterials should interact with its host and possess properties like bioactivity and biofunctionality. They should support and promote the healing process and in some specific clinical indications (e.g. trauma), they should progressively degrade and be ex- or included by the organism after their work is fulfilled. These requirements opened up a new field of research and gained increasing interest of material scientists as well as molecular biologists and physicians around the world in the last decade. Currently targeted clinical applications for such biodegradable materials that combine mechanical requirements and biological demands are cardiovascular stent application and orthopaedic surgery. Magnesium is one of those promising materials as it is not only an essential element in the human organism, but also a light metal with mechanical properties that are close to the natural bone with the ability to degrade in any aqueous solution. The focus of this thesis was to examine the biological properties of Mg-alloys with special regard on biodegradation, bone-implant-interface, biocompatibility and biofunctionality. It has been shown that Mg-alloys can fulfil all requirements for an orthopaedic application due to its promising mechanical, electrochemical, and biological properties. The latter however is the most essential issue for a successful clinical application. Future development strategies of Mg-alloys therefore need to address material purification, non-toxic endogenous alloying elements, and strategies for a homogenous gradual degradation process.