Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Celebi, N.
Immobilization and Hormonal Changes
Humanmedizin; [ Diplomarbeit/Master Thesis (UNI) ] Graz Medical University; 2015. pp.65.
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Goswami Nandu
- Altmetrics:
- Abstract:
- Background and aim of the study: Long-term bed rest caused by several diseases has effects on the cardiovascular system. Adrenomedullin and Galanin are two of several hormones, which are involved in the regulation of blood and heart system. In this study we investigated the adjustment of the Adrenomedullin and Galanin expression during a long-term bed rest with a head down tilt position of 6 ° (HDT 6°) simulating microgravity. Methods and Materials: The randomized cross over study was carried out 12 healthy men at MEDES, Toulouse. The subjects stayed in bed rest for 21 days with a head down tilt position of 6 ° (HDT 6°), so as to simulate the effects of microgravity induced fluid shifts. Blood samples were taken before, during and after the long-term bed rest. Blood samples were analyzed for Adrenomedullin and Galanin concentrations at the Medical University of Graz. Results: All participants showed an increase in Adrenomedullin and Galanin values. The concentration of Adrenomedullin rose +29 % from the beginning until the end of the study however two days after the end of the study it was only +19 %. For the same duration the Galanin concentration increased by 49 % and kept on increasing two days after completion of the study and reached values of 56 %. Discussion: We observed significant increases of the concentration of Adrenomedullin and Galanin from the 14th day of the study. Our assumption is that an alteration of hydrostatical load distribution and fluid shift within the blood vessels and the heart chambers causes the increased concentration. One hypothesis for the increase of ADM is the tissue- and cardio- protective function of this hormone during immobilization. The rise of the Galanin values could depend on greater effects of the sympathetic nervous system of the subjects in long-term bed rest (Christensen, et al. 2005). By a higher function of the sympathetic nervous system Galanin is released in an extended way like we could have seen in our study.