Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Sabo, C.
Clinical data analysis of aggressive B-Non-Hodgkin lymphomas
Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2014. pp. 66
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Neumeister Peter
- Prochazka Katharina
- Altmetrics:
- Abstract:
- Background: Diffuse large B-cell lymphomas (DLBCL) represent the most common group of Non-Hodgkin lymphomas. The roles of GGT, uric acid and BMI as laboratory values in cancer genesis have been discussed in several studies, though in this entity the data situation is still unclear. GGT and uric acid seem to have an antioxidant effect. However a high BMI seems to have an effect on the immune system and the inflammatory response. In this thesis the influence of high or normal GGT (>45U/l vs. ≤45 U/l), uric acid (>6,5mg/dl vs ≤ 6,5mg/dl) and BMI (>25 vs. ≤25) on DLBCL patients’ overall survival was analyzed in a retrospective study. Material and Methods: This retrospective study is based on a database, containing 382 patients diagnosed with DLBCL at the Medical University of Graz. GGT, uric acid and BMI values have been documented using the MEDOC system of the University Hospital Graz. Afterwards, statistical analysis was performed for these parameters by using the Statistical Package for Social Sciences version 21.0 and 22.0 (SPSS inc., Chicago, IL, USA). Additionally, Excel version 2010 was used to create tables and pie charts. For the statistical analysis we used a x2-test, Kaplan-Meier curves and log rank test were created to show the probability of survival. Univariate and multivariate analysis were performed by using Cox regression. Results: A significant difference of the probability of survival was found for uric acid values by using Kaplan-Meier curves and log rank test for the benefit of uric acid values ≤6,5 mg/dl (p=0,002). The univariate Cox analysis showed that older age (50-75a p=0,042 and >75a p=0,002), a poor R-IPI (p=0,003), the subtype (GCB vs NGCB p<0,001), elevated uric acid (>6,5 mg/dl, p=0,003), elevated LDH (≤243 U/l vs >243 U/l, p=0,006), elevated CRP (≥10 mg/l, p=0,017) and low hemoglobin (<12 g/dl, p<0,001) correlate with a poor OS. The data of the multivariate Cox regression indicated that subtype (p=0,005), elevated uric acid (p=0,004) as well as low hemoglobin levels (p=0,003) are independent prognostic factors for OS. Conclusion: In conclusion, we demonstrated that high uric acid levels, at the time of DLBCL diagnosis, act as an independent poor prognostic factor for the overall survival.