Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Tmava, A.
Immobilization Induced Coagulatory Changes: A Literature Review
Humanmedizin; [ Diplomarbeit ] ; 2014. pp. 54
[OPEN ACCESS]
FullText
- Autor*innen der Med Uni Graz:
- Tmava-Berisha Adelina
- Betreuer*innen:
- Goswami Nandu
- Hinghofer-Szalkay Helmut
- Altmetrics:
- Abstract:
- Bed rest immobilization has been suggested to affect coagulation. However, up to today there is no consensus on the reported data: some studies suggest that there is a tendency to hyper clot while others have not reported such effects of immobilization. This diploma thesis explores the physiological basis of coagulation, and then discusses current literature that shows how immobilization effects coagulation. The aim is to search the existing literature and provide current state of the art knowledge with regards to how coagulation is regulated, paying particular attention to anti- as well as pro-thrombotic mechanisms. Is it possible that the increased tendency to clot is complemented by increased anti-thrombotic activity, leading to no net effects in coagulation during immobilization? This diploma thesis will search for the latest articles that show what happens during bed rest immobilization with particular emphasis on coagulation. The effects of different postural changes as well as stress hormones and sitting immobilization on coagulation will be explored. The relationship to differences in methodologies, subject/ patient selection, types of interventions as well as differences in protocols are going to be discussed. To obtain the relevant literature related to my topic I used PubMed as primary database. Explored were articles written in English or German, publicized from 1957 till 2014. Abstracts plus full texts were included as primary literature. Furthermore, Web of Science database as well as the list of References were also used to find articles related to the area of search. Books particularly physiology and pathophysiology books were used as secondary literature. Refworks was used to save and organize the references. The knowledge gained from this work would be particularly relevant to those future medical practitioners who have an interest in working in the area of falls, orthopedics or thrombosis research.