Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
De Simoni, D.
Is Dobrava virus enzoonotic in Styrian yellow-necked mice?
Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2014. pp. 66
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Krause Robert
- Altmetrics:
- Abstract:
- Hantavirus diseases are emerging zoonoses with two manifestations of infection, Hantavirus Cardiopulmonary Syndrome in America and Hemorrhagic fever with renal syndrome in Eurasia. The case load is escalating worldwide and new viruses are found constantly in new territories. Transmission occurs via aerosolized excreta of carrier rodents. In Austria only Puumala and Tula virus were known to be endemic. In 2011, a case of presumably autochthonous acquired infection with a strain that was not known to circulate in the country before, was reported. This type, namely Dobrava-Belgrade virus, causes a more severe course of disease, with fatality rates of up to 12 %. Its reservoir, the yellow necked mouse, is widely distributed Austria. In order to prove the virus persistence in Styria, mousing was undertaken in the suspected area of virus acquisition and mice were screened for Hantavirus RNA via RT-PCR. No Dobrava-Belgrade virus was detected. However, physicians should be aware of this hazardous type which propagation in Austria could not be excluded. The current thesis contains the actual knowledge about Hantaviruses in general, Dobrava-Belgrade virus in particular, the case report and our research project targeting the existence of Dobrava-Belgrade virus in local mice.