Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wolf, S.
Immobilization and Coagulation: Molecular mechanisms
Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2014. pp. 48
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Goswami Nandu
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- Abstract:
- Background: An increased blood clotting and its further complication thrombosis are associated with longterm Bed rest (BR). The molecular background with its possibility of changed expression in genes of the coagulation system was not studied until now. In this study we want to show the gene expression and the connection between the blood clotting system. Materials and Methods: In this randomized, cross-over study we investigated the gene expression closely linked to coagulation in 12 healthy young men during longterm BR with head down tilt position 6° (HDT 6°). Blood samples were taken before, during and after BR. We used microarray technology to measure gene expression changes. Results: All study subjects showed individual expression of coagulation genes due to immobilization. Only the expression of two genes (thrombin & plasminogen activator) were significant in t-est (p-value <0.05). Most of coagulation genes of study subjects did not change their expression significantly. Discussion: The results of this study showed that bed rest itself showed no increased gene expression concerning the coagulation system. We think that additional factors such as major surgery are reasons of an increased coagulation.