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Ameur, N.
Oxidative stress in patients with thyroidal dysfunction - analytical determination of the oxidative stress marker 4-HNE (4-Hydroxy-2-nonenal) by gas chromatography-mass spectrometry
Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2014. pp. 67 [OPEN ACCESS]
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Authors Med Uni Graz:
Advisor:: Fauler Günter
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Abstract:: Oxidative stress (OS) causes aberrations of the oxidant-antioxidant balance and is implicated in various path physiologies like diabetes, atherosclerosis, ageing and neurological disorders. One of the most frequently used markers of oxidative stress is 4-Hydroxy-2-nonenal (4-HNE), a secondary product of lipid peroxidation. 4-HNE has already been ascribed to various neurotrophic and cardiovascular events. The impact of oxidative stress on thyroidal dysfunction has not been investigated to date. The aim of this study was to determine the oxidative stress status of patients with thyroidal dysfunction by investigating patients’ 4-HNE serum values. This was achieved by determining 4-HNE via capillary column gas chromatography-negative-ion chemical ionization mass spectrometry.