Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Labacher, M.
The impact of thyroid therapy, both in hypo- and hyperthyroid patients on cardiovascular risk
Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2014. pp. 64
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Gruber Hans-Jürgen
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- Abstract:
- Introduction The various thyroid diseases, including hyper-, eu- or hypothyroidism, represent a complex network depending on the functional behaviour of the thyroid, which is the basis for diagnosis and therapy. The aim of the present study is to investigate the implication of thyroid therapy and the related cardiovascular risk factors both in hyper- and hypothyroid patients. We hypothesise that thyroid dysfunctions are associated with cardiovascular risk factors and therefore thyroid therapy intervenes as prophylaxis for cardiovascular diseases after achieving normal state in patients. Patients In our case-based study we investigated a total number of 96 subjects. Patients were sub-grouped regarding their thyroid function into hyper- hypo and euthyroid. We analysed baseline characteristics including thyroid, lipid and anthropometric parameters at the beginning of the study and in the follow up after 6 months of treatment. Results Patients displayed significant thyroid abnormalities according to their underlying thyroid disorder. Further probands featured alterations of lipid, systolic and diastolic blood pressure levels. After 6 months of treatment hypothyroid patients revealed significantly lower ft 3 levels. Analyses exhibited significant differences of BMI, waist circumference, waist-to-length ratio and diastolic blood pressure in euthyroid and significant changes in systolic blood pressure in hypothyroid patients. We found significant variations of HDL in hypothyroids and of LDL/HDL- ratio in hypothyroids just as in euthyroids. Investigation of ADMA unveiled significant low levels in hyper- and euthyroid patients and even highly significant low ones in hypothyroids. No significant changes were found regarding inflammatory parameters. Regression analyses revealed significant correlation between thyroid hormones and lipid parameters, especially HDL and LDL. Conclusion Recapitulating, our findings suggest a preventive impact of thyroid therapy in normal weight patients on atherosclerosis and subsequently on cardiovascular disease both in hypo- and hyperthyroidism. However, we have to notice that the present study is a pilot study and findings have to be proven in further clinical trials. Interpretation/Future perspective Further research is required to clarify the influence of various degrees of thyroid dysfunction in the development of atherosclerosis and cardiovascular morbidity, especially in terms of therapeutic approaches in obese patients.