Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Feichtner, F.
Continuous blood glucose monitoring using microdialysis.
[ Dissertation ] Graz University of Technology / Joanneum Research; 2013. pp.161.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Ellmerer Martin
- Schaupp Lukas
- Altmetrics:
- Abstract:
- Driven by the reported medical benefit of (tight) glycaemic control of ICU patients the EC funded project CLINICIP was initialized. CLINICIP aimed to develop a system for closed loop insulin infusion in critically ill patients. This thesis is embedded in CLINICIP and focussed on the development, the technical and clinical evaluation of an extravascular microdialysis based body interface for continuous glucose monitoring. Several approaches were investigated technically and in a risk assessment study in order to find an appropriate design and optimal operating conditions. The final design of the developed body interface features a system for continuous blood withdrawal and a planar flow-through microdialyser that delivers a protein-free blood dialysate. Following a stepwise approach, this body interface was further combined with spectrometric and amperometric online glucose sensors and later on with an algorithm to function as a continuous glucose monitoring and regulation system. The technical and clinical performance evaluations of this system and its subsystems were done in clinical studies in healthy volunteers and type 1 diabetes mellitus patients. Results from these investigations using the extravascular microdialysis approach were published peer-reviewed as first author. The results of a comparison to similar tests using subcutaneous microdialysis probes were peer-reviewed published as co-author.