Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Ujvari, A.
Sensitivity and specificity of new serum blood parameters like Procalcitonin, Interleukin-6, Fibrinogen and Interferon-alpha in the field of orthopaedic surgery
[ Diplomarbeit ] Medical University of Graz; 2011. pp. 58 [OPEN ACCESS]
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Autor*innen der Med Uni Graz:
Betreuer*innen:: Glehr Mathias; Leithner Andreas
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Abstract:: Background: Periprosthetic joint infection (PJI) is still a severe problem after total hip and knee arthorplasty. One of the most important steps in the diagnostic process of detecting PJI remains the analysis of laboratory infection parameters. The aim of this study was to investigate the sensitivity and specificity of the serum parameters procalcitonin (PCT), interleukin-6 (IL-6), fibrinogen (FBG) and interferon-alpha (IFN-alpha) in comparison to conventional parameters (leukocyte count),C-reactive protein(CRP)) in the field of orthopaedic surgery. Methods: Eighty-four patients (124 operations) were prospectively included. The blood parameters of interest were PCT, IL-6, FGB, IFN-alpha, leukocyte count and CRP. Samples were taken preoperatively and the first, the third and the seventh postoperative days. Samples of FBG were taken only preoperatively. The sensitivity and specificity of these parameters were calculated. Results: Considering all 124 operations, PCT (p=0.038), IL-6 (P=0.012), FBG (p<0.001), the leukocyte count (p<0.001) and CRP (p<0.001) had a statistically significant correlation with a positive histology for infections, while IFN-alpha (p=0.432) did not. Discussion: Conventional parameters of infection (CRP and leukocyte count) were superior to PCT, IL-6 and FBG in detecting joint infection. It might be helpful to additionally analyse PCT, IL-6 and FBG in special cases, i.e. when it is unclear whether there is a bacterial joint/implant infection or an aspetic inlammation and when it is important to analyse the impact of antibiotic therapy.