Medizinische Universität Graz - Research portal
Selected Publication:
Trennheuser, M.
Metal ion levels in patients before and after total hip arthroplasty with metal-on-metal large-head bearing: Intermediate data at one year follow-up
[ Diplomarbeit ] Medical University of Graz, 2011. pp. 84
[OPEN ACCESS]
FullText
- Authors Med Uni Graz:
- Advisor:
- Maurer-Ertl Werner
- Altmetrics:
- Abstract:
- Background: Elevated metal ion levels are one of the main concerns about metal-on-metal THAs because of their possible side effects like neuropathy following cobalt intoxication, higher revision rates, pseudotumours, or chromosomal aberrations in peripheral blood. In this context, former studies revealed a correlation between the inclination or rather the arc of cover of the acetabular cup and metal ion levels in the serum. In our study we tried to figure out if this correlation can also be found in patients treated at our hospital with the DePuy ASR Resurfacing System and DePuy ASR XL Head System. Methods: In this prospective, non-randomised monocentre study we determined metal ion levels in the serum of cobalt and chromium in 36 patients (40 THAs; eight DePuy ASR System and 32 DePuy ASR XL Head System) four times: preoperatively, one week, three months and one year post-operatively. Additional radiographs of the pelvis and the affected hip in two planes were taken at the same follow-up points of time. The cup inclination was measured by two independent observers and the arc of cover was calculated referring to the publication of De Haan et al. Finally, we did a correlation analysis following Pearson and Spearman. Results: Mean concentrations of metal ions in serum one year post-operatively were 0.51 µg/dl for cobalt and 0.53 µg/dl for chromium. We found no significant correlation between the cup inclination or rather the arc of cover and metal ion level in the serum within our study group. Conclusion: Within our study group we could neither confirm nor refute a statistical significant correlation between the cup inclination or the arc of cover and metal ion levels in the serum at one year follow-up. These findings may be due to the small amount of THAs in the steep group with a cup inclination of more than 55° or rather the group with an arc of cover less than 10 mm. Nevertheless, based on these findings further research will take place about this issue at our department to identify further influences on metal ion levels in serum and to learn more about these.