Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Boder, V.
Association between vitamin D and carotid intimamedia thickness in hypertensive women and men -
Assoziation zwischen Vitamin D und Karotis Intima- Media Dicke in einem hypertensiven Kollektiv
[ Diplomarbeit ] Medical University of Graz; 2011. pp. 83
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Pilz Stefan
- Tomaschitz Andreas
- Altmetrics:
- Abstract:
- Background: A poor vitamin D status has been related to an increased risk of cardiovascular disease. This is supported by the confirmed association of traditional cardiovascular risk factors with low levels of 25-hydroxyvitamin D. Carotid intima media thickness has shown to be a marker of evident as well as of subclinical atherosclerotic disease. Therefore we aimed at examining the association between vitamin D status and the extent of carotid intima media thickness. Patients and Methods: The study included 88 patients from the GECOH study. The patients were referred to the Department of Endocrinology for investigation for potential endocrine hypertension. Assessment of all anthropometrical, clinical and biochemical parameters was performed according to the study protocol. For the assessment of 25-OH-D levels a chemiluminesence assay was applied. Intima media thickness of the common carotid artery was evaluated by B-mode ultrasound. Results: Vitamin D deficiency was prevalent among 17.0% (¿16 ng/ml) and either measurement of carotid intima media thickness revealed increased values for both sexes. Correlation analysis did not reveal a significant association between 25-OH-D and CIMT, but a strong non-significant trend for the overall cohort (p=0.095) and for the male subjects (p=0.078). The trends across adjusted 25-OH-D tertiles to be associated with CIMT presented a borderline significant variation for the minimally (p=0.063) and moderately (p=0.065) adjusted models. This tendency disappeared after further adjustment. There was a significant difference for the adjusted mean CCA-IMT in the first versus the third and in the first versus the second tertile to be observed. Conclusion: Although we failed to confirm a significant association between vitamin D status and carotid intima thickness, our findings of strong non-significant trends suggest that there might be a relationship.