Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Tomljenovic Masic, A.
Influence of gender on the in vivo pharmacokinetics of propofol
[ Diplomarbeit/Master Thesis ] Medical University of Graz; 2011. pp.43.
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Bornemann-Cimenti Helmar
- Altmetrics:
- Abstract:
- Background Females and males have different body compositions. The body fat percentage is larger and the body water content is smaller in females. Furthermore, these differences are age-dependent, with body fat increasing in both genders with age. Body fat composition may affect the volume of distribution of many drugs. For lipophilic drugs such as opioids and benzodiazepines, the volume of distribution per kg body weight generally will be higher in females than in males. Materials and Methods Serial arterial blood samples (approximately 4 ml) will be withdrawn before induction (Pt0) and at 1, 3, 5, 7, 10, 15, 20, 25, 30, 60, 90 and 120 min following propofol administration. During the blood samples acquisition part of the study, the levels of anesthesia were maintained using sevoflurane inhalational anesthesia to avoid additional propofol administration. Within minutes of samples acquisition, plasma was isolated by 2500 g centrifugation for 10 min. Blood samples was immediately extracted, acidified and stored frozen to prevent degradation by adding buffer to 1 ml plasma, carefully mixed and subsequently stored at 20oC. Results There were no significant differences between the two gender regarding the propofol plasma concentrations, mean arterial pressure, estimated blood losses, fluid replacements, remifentanil doses during the 120 min blood sample acquisition part of the study. Conclusion In conclusion, we demonstrated that no significant differences in propofol plasma concentrations between males and females. Given our observed results of no clear real differences between the 2 genders, larger studies are not warranted to explore the potential differences between genders that may contribute to our understanding of these differences.