Medizinische Universität Graz - Research portal
Selected Publication:
Pivec, C.
ATGL & OLANZAPINE - Interactions with the lipid metabolism
[ Diplomarbeit ] Medical University of Graz; 2011. pp. 70
[OPEN ACCESS]
FullText
- Authors Med Uni Graz:
- Advisor:
- Gorkiewicz Gregor
- Höfler Gerald
- Altmetrics:
- Abstract:
- Knowing a lot about effects on the central nervous system, we only know few about the cellular effects of olanzapine, such as its impacts on the lipid metabolism which seems to play an essential role in olanzapines side effects and opens a door to a novel research focus. From the metabolic side of view, obesity is a pathological accumulation of fat and white adipose tissue. So becoming obese is a homeostasis between triacylglycerol (TAG) synthesis and triacylglcerol degradation whereas a shift from degradation to synthesis results in TAG accumulation, which results in obesity. Responsible for the breakdown of TAG¿s are lipases such as ATGL, HSL and MGL. Previously, HSL was considered to be the rate-limiting enzyme in TAG degradation. But in 2004, three different groups reported an enzyme, which seems to be the rate-limiting enzyme in TAG breakdown. This enzyme is commonly known as adipose triglyceride lipase (ATGL). Many results indicate that ATGL is the rate-limiting enzyme on TG breakdown, whereas HSL is mainly responsible for DG breakdown. The last lipase in the TG breakdown pathway is monoglyceride lipas (MGL) which hydrolyzes monoglycerides to glycerol and one fatty acid. Until now it seems like no one investigated the effects of olanzapine on the entire TAG breakdown including ATGL, the major enzyme of lipolysis and so the aim of our studies is olanzapine and its effects on lipolysis on cellular level.