Medizinische Universität Graz - Research portal
Selected Publication:
Breuer, T.
Klinisches Spektrum und Outcome von Erwachsenen mit angeborenem Herzfehler (EMAH) und Syndromen
[ Diplomarbeit ] Medical University of Graz; 2010. pp. 58
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- Authors Med Uni Graz:
- Advisor:
- Gamillscheg Andreas
- Nagel Bert Hermann Philipp
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- Abstract:
- Introduction: Despite the growing number of adult patients with congenital heart defects (ACHD), there is no sufficient data for long- term follow- up of ACHD with syndrome. The aim of this study was to evaluate ACHD with syndrome at the Division of Pediatric Cardiology from the Medical University of Graz in comparison to ACHD without syndrome and to detect risk factors for outcome. Methods: Retrospectively data reviewed of 69 ACHD with syndrome (35 male, 34 female) with a mean age of 26.7 years (range:18.8 to 53.3 years) was analyzed. The largest group of patients in this study were 32 ACHD with Down¿s syndrome (20 male, 12 female), who also were compared to ACHD without syndrome. Results: The most common diagnoses were VSD (n=17; 24%), ASD I or ASD II (n=16; 23%), prolapse of the mitral valve (n=10; 14%), TOF (n=8; 11%) and atrioventricular canal (n=8; 11%). 18 surgical procedures on 14 adult patients had been performed, in detail there were 11 pacemaker- ops ( 61%), 5 correction ops (27 %), and 1 revision op and one palliative op (each 5 %). 49 patients underwent 92 cardiac catheter procedures, 84 in childhood (91%) and 8 during adulthood (8%). There had been 7 cardiac catheter procedures for diagnostic reasons and 1 for interventional reason. 6 postoperative complications occurred in 5 cases: 2 AV- block¿s III (33 %), 2 residual VSD¿s (33 %), 1 fistula between VCS and LA (16 %) and 1 sinus node dysfunction (16 %). 2 patients suffering from Down¿s syndrome and dysmorphic syndrome died, but cause of death remains unclear. 50 % of all evaluated ACHD- patients were classified NYHA I, another 49 % were in NYHA II and above. Even 53 % of ACHD with Down¿s syndrome were placed in NYHA ¿ II and showed cardiological disabilities. Discussion: This study showed a syndrome- specific variety of congenital heart defects. The most common surgical procedures were pacemaker ops. Postoperative complications occurred frequently (27 %) and mortality was rare. ACHD with syndrome were more frequently classified to have cardiological disabilities than ACHD without syndrome.