Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Strohmeier, B.
Intradermal Testing in Hymenoptera Venom Allergy
[ Diplomarbeit/Master Thesis ] Medical University of Graz; 2010. pp. 46
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Aberer Werner
- Sturm Gunter
- Altmetrics:
- Abstract:
- Introduction: According to current guidelines intradermal testing with Hymenoptera venom should be performed stepwise with 15-20 min breaks after each injection of venom. In this study, we administered different venom doses during intradermal testing simultaneously to save time for the diagnostic procedure. The objective of the present study was to determine the frequency of adverse reactions of simultaneous intradermal testing. Patients and Methods: Simultaneous intradermal testing with concentrations of 0.00001, 0.0001, 0.001, 0.01, 0.1, and 1 µg/ml Hymenoptera venom was performed in 484 patients who experienced anaphylactic reactions after a Hymenoptera sting. An intravenous line was inserted before testing. The respective test protocols and documented adverse reactions were collected and analyzed. Results: 6 of 484 (1.2 %) patients suffered from side effects during simultaneous intradermal testing: 2 showed symptoms of vasovagal disorder after insertion of the intravenous line; 3 subjects felt dizziness, sensation of heat and dyspnea during the test; only one patient suffered from a clear anaphylactic reaction with red flush on the site of the test, shivering and nausea, but without tachycardia or hypotension. Conclusion: Simultaneous intradermal testing is time-saving and safe in the diagnosis of Hymenoptera venom allergy. Large prospective studies are needed to evaluate the frequency of side effects during simultaneous intradermal testing.