Medizinische Universität Graz - Research portal
Selected Publication:
Iro, E.
Clinical relevance of urogenital colonization with mycoplasma hominis and ureaplasma urealyticum in patients undergoing elective hysterectomy
[ Dissertation ] Medical University of Graz; 2002. pp.
- Authors Med Uni Graz:
- Advisor:
- Marth Egon
- Wenisch Christoph
- Altmetrics:
- Abstract:
- Mycoplasma hominis und Ureaplasma urelyticum belong to the family of the mollicutes, a family of bacteria lacking a cell wall and bounded by a triple layered cell membrane containing sterols, which can not be fund in any other bacteria of virus. They have a very small size which enables them to pass through filters with pore size that retains bacteria. When first discovered, they were therefore assumed to be viruses. Mycoplasmas are ubiquitous bacteria and colonize in plants and animals. They are the smallest form of life capable of replication outside host cells. Urogenital mycoplasmas colonize in the urogenitourinary tract asymptomatically, but can also cause disease which can be locally e.g. urethritis and bacterial vaginosis, but also systemically like pyelonephritis, feverish diseases and even more severe diseases mostly in infants and immunocompromised patients. In people with lower genitourinary tract colonization Mycoplasma hominis and Ureaplasma urealyticum can invade the upper urinary tract leading to clinical entities such as: Pyelonephritis, Bacterial vaginosis, Pelvic inflammatory disease (PID) Prostatitis and epididimitis, Infertility, Postabortion and postpartum fever, Nephrolithiasis, Diseases in newborn: respiratory disease and diseases of the central nervous system (CNS), Extragenital diseases: septicaemia, joint infections, local suppurative infections, wound infections. There are three main methods of mycoplasmal diagnosis: Culture, serology and PCR. In this study the Polymerase Chain Reaction (PCR) was used for the detection of the two mycoplasma species in the urine and blood samples, because the PCR provides a higher sensitivity than cultural detection. Additionally cultural detection takes more time. There are no data available concerning the frequency of colonization with urogential mycoplasmas in Austria. The first aim of his study was to establish the rate of colonization of Mycoplasma hominis and Ureaplasma urealyticum in females. The second aim was to investigate the incidence of bacteraemia with these two organisms after hysterectomy. 56 patients undergoing hysterectomy were included in this study.