Medizinische Universität Graz - Research portal
Selected Publication:
Abdulai, M.
Postoperative Analgesia Requirements Following the Use of Octreotide (Sandostatine) vs. Control Patients
[ Dissertation ] Medical University of Graz; 2008.
- Authors Med Uni Graz:
- Advisor:
- Metzler Helfried
- Altmetrics:
- Abstract:
- 1. Introduction: Although several studies have examined the post surgical analgesic effect of Somatostatin, the analgesic effect of Octreotide could not be proved. 2. Aim of the study: The purpose of our study was to prove the post surgical pain reduction of the Somatostatin-Analogon octreotid as an alternative analgesic. Can Octreotid be used as an additive to Opioids for pain treatment and does Octreotid have an Opioids sparing effect post surgical long-term medication? 3. Patients and methods. All patients who agreed to participate in the study gave a written informed consent. 44 American Society of Anesthesiologists (ASA) classification I-II patients, undergoing abdominal surgical procedures were recruited on our study. 22 of the controlling patients were applicated with Piritramid over a PCA pump, the remaining 22 patients with Octreotid and Piritramid. 4. Results: The essential result of our study was the different consumption of Piritramid in both groups and the pain intensity. These both changes were registered within the first 22 hours. The result was that Octreotid-patients had on the one hand less pain and on the other hand needed less Piritramid. This was confirmed by the absence of significant changes of the indirect pain sensation parameters like arterial pressure, heart frequency and VAS (visual analog scale) which could be proved within Octreotid-patients. 5. Discussion: There are only a few reports on the effectiveness of Octreotid, concerning the post surgical painlessness. In the double blind study form DAlessandro R. et al. 20 patients were applicated 250 g Octreoide s.c. post surgically and when required received more. Besides, 4 hours-pain sensation was reduced about 92%. The placebo patients showed no changes of the pain sensation. Further there were no side effects of haemodynamic changes. The efficiency of Octreotid concerning the management of post surgical pain is proved. Also in our study the good results of Octreotid concerning the post surgical pain sensation and the decrease of the need in Piritramid have been confirmed.