Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Vagena, F.
NPM-ALK Expression in Hodgkin Lymphoma and Review on Hodkin Lymphoma
[ Dissertation ] Medical University of Graz; 2003. pp.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Beham-Schmid Christine
- Altmetrics:
- Abstract:
- History: In the year 1832 Dr. Thomas Hodgkin described the disease we now know as the Hodgkin lymphoma. He published this entity in the paper on some morbid appearances of the absorbend glands and spleen. The histological description of Hodgkin lymphoma was done 60 years later 1892 by Carl Sternberg, who suggested at that time that the Hodgkin lymphoma might be a certain variant of tuberculosis. Finally in the year 1902 Dorothy Reed occupied herself with the Hodgkin lymphoma and its histological appearance. The Hodgkin lymphoma is a malignant lymphoma which commonly appears in the lymph nodes, but theoretically almost any other localisation is possible. It is to distinguish between the lymphocyte predominant Hodgkin lymphoma (LPHL) and the classical Hodgkin lymphoma (CHL). Its aetiology is still unknown, however, an Epstein Barr Virus infection, is suspected to play a role in the development of this lymphoma. The T-Cell anaplastic large cell lymphoma (T-ALCL) has some similarities to the Hodgkin lymphoma, as well morphologically, as immunohistochemically. NPM-ALK (Nucleophosmin-Anaplastic lymphoma kinase) is a fusion protein created by the reciprocal balanced translocation t(2;5)(p23;q35). It appears quite often in the T-ALCL, and it is said to be associated with a better prognosis. Because of the similarities between Hodgkin lymphoma and T-ALCL, it was investigated, if this translocation can also detected in Hodgkin lymphomas. The results of the studies done on this topic were controversial. In this study the t(2;5)(p23;q35) translocation could be detected immunohistochemically in 28/54 Hodgkin lymphomas. This might lead to the conclusion that there is a close relation between T-ALCL and the Hodgkin lymphoma. In our study, no significant differences concerning histology, immunohistochemistry and prognosis were observed between the NPM-ALK-positive and the NPM-ALK-negative Hodgkin lymphoma cases.