Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Peteani, R.
Comparison of clinical and pathological parameters between clinically localised prostate cancer diagnosed in the first biopsy and saturation-rebiopsy
[ Diplomarbeit ] Medical University of Graz; 2008. pp.75
[OPEN ACCESS]
FullText
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Augustin Herbert
- Auprich Marco
- Altmetrics:
- Abstract:
- Objective: To compare clinical and pathological parameters between clinically localised prostate cancer (PC) diagnosed in the first biopsy and saturation-rebiopsy. Patients and methods: Between January 2005 and December 2007, a consecutive series of 428 men with clinically localised PC underwent retropubic radical prostatectomy (RRP) and pelvic lymphadenectomy at the Department of Urology, University Hospital of Graz, Austria. Patients with PC were diagnosed by first core-biopsy (group1) or by 24-core-saturation-rebiopsy (group 2). Clinical and pathological parameters were entered into a computer database and analysed using SPSS 14.0. Results: Overall, 256 patients were eligible for analysis. Men were separated into two groups. 201 patients with a mean age of 61.1 years were included in group 1. Group 2 consisted of 55 patients with a mean age of 61.7 years (P=0.633).The median serum PSA was 5.9 ng/mL in group 1 and 7.8 ng/mL in group 2 (P=0.372), respectively. The median PSA ratio was 11% in both groups (P=0.596). In the initial biopsy set the number of cores ranged between 6 and 12 (mean 8.6). In group 2 patients underwent between 1 and 8 rebiopsies (mean 2.5). 37.7% of cores in group 1 and 17.6% in group 2 were diagnosed with PC (P=0.000). 33.6% of DRE in group 1 and 10.6% in group 2 were suspicious (P=0.002). The present study showed exact agreement of needle biopsy Gleason Scores and RRP Gleason Score in 45.7% in group 1 and 51.9% in group 2. Under-grading in group 1 (47.2%) and in group 2 (34.6%) was more frequent than over-grading with 7.1% and 13.5%, respectively. Cohens kappa coefficient was in group 1 0.250 and V 0.356 in group 2. Kendall b coefficient confirmed low agreement in group 1 (0.390) as well as a moderate one in group 2 (0.496). Conclusion: Group 2 showed a decreased rate of positive cores, even though more prostatic tissue was taken. The majority of suspicious DRE was registered in patients with first core-biopsy. Cohens kappa coefficient of Gleason Scores between biopsy specimen and RRP specimen was higher in group 2.