Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Jaju, D.
Blood Pressure and Cardiovascular Control in Offspring of Hypertensive and Normotensive Parents from Large Homogeneous Omani Arab Pedigrees
[ Dissertation ] Medical University of Graz; 2008. pp.110
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Pessenhofer Herfried
- Altmetrics:
- Abstract:
- Offspring of normotensive (ONT), one (OHT1) and both hypertensive (OHT2) parents from large homogeneous Omani Arab pedigrees were subjected to ambulatory blood pressure (ABP) measurements. Beat-to-beat BP, impedance cardiography and heart rate and BP variability acquired at rest and during cold pressor (CPT), head-up tilt (HUT), word conflict and deep breathing test showed that OHT2 have more responsive resistance vessels at a time when BP is normal. Hence, they can afford less sympathetic nervous system (SNS) (LFnuRRI) activation at rest and during HUT. This finding is corroborated by a significant correlation between change of LFnuRRI and plasma noradrenaline. If mental stress is imposed, OHT2 respond with greater activity of HR and SNS. This is also reflected in higher HR in ABP. CPT could not differentiate offspring with positive and negative family history of hypertension. Inconsistent cardiovascular and autonomic alterations in OHT1 in contrast with ONT and OHT2 showed the importance of predisposition of hypertension (HT) in one or both parents. Pathophysiological changes affecting resistance vessels and SNS are evident in OHT2 before the onset of HT. The cross-sectional analysis indicated that, subjects with high normal BP/preHT are likely have increased parental history of HT compared with subjects having optimum BP