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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Yang, LZ; Tovote, P; Rayner, M; Kockskamper, J; Pieske, B; Spiess, J.
Corticotropin-releasing factor receptors and urocortins, links between the brain and the heart.
Eur J Pharmacol. 2010; 632(1-3):1-6
Doi: 10.1016/j.ejphar.2010.01.027
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- Co-authors Med Uni Graz
- Kockskämper Jens
- Pieske Burkert Mathias
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- Abstract:
- Corticotropin-releasing factor (CRF), a 41 amino acid peptide, was discovered as a key signal in mediating neuroendocrine, autonomic, and behavioral responses to stress. It was revealed later that there exist additional CRF-like peptides, termed urocortins. The CRF receptor subtype 1 (CRF1 receptor) is predominant in the brain whereas subtype 2 (CRF2 receptor) is highly expressed in the brain and the heart. Both centrally and peripherally administered CRF and urocortins produce significant hemodynamic effects via activation of CRF receptors in the brain and the heart. CRF and urocortins are important neural and cardioactive hormones, and are potentially useful therapy for heart failure.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autonomic Nervous System - metabolism
- Brain - metabolism
- Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - physiology
- Mice -
- Peptides - metabolism
- Rats -
- Receptors, Corticotropin-Releasing Hormone - metabolism Receptors, Corticotropin-Releasing Hormone - physiology
- Urocortins -
- Find related publications in this database (Keywords)
- Endocrinology
- Corticotropin-releasing factor
- Urocortins
- Brain
- Heart